Effect of omega 3 fatty acid on the diabetes in rattus rattus var albinus

Abstract

This study aimed to determine the effect of omega 3 on the blood glucose in diabetes induced in Rattus rattus variety albinus. The research was conducted at the Faculty of Medical Sciences of the Universidad César Vallejo Trujillo. They worked with 15 female rats which were separated into three groups of 5 rats, G1: Experimental group with diabetes induced with a single dose of alloxan 85 mg/Kg intraperitoneally and then treatment with omega-3,57mg / kg orally for 5 days (treated diabetic group); G2: Experimental group with single dose of alloxan (untreated diabetic group); and G3: Control group. The diabetic group with treatment had an average basal glucose of 228.4 ± 52,07mg/dl, after administration of omega-3 to 14, 21 and 28 days presented an average blood glucose of 166.2 ± 71,93mg/dl; 88.6 ± 19.73 mg/dl; 85.8 ± 5,54mg/dl respectively. The untreated diabetic group had a mean baseline blood glucose of 298 ± 153,54mg/dl and to 14; 21 and 28 days reached levels of 309.8 ± 171,44mg/dl; 285.8 ± 144,22mg/dl; 309.8 ± 170,83mg/dl; observed in them characteristics of polydipsia, polyphagia, polyuria and smell of ketones. Comparing blood glucose between the groups with induced diabetes treated omega 3 and without treatment; it was observed that on day 28 diabetic treatment group had a final glucose 85.8 ± 5,54mg/dl while the untreated diabetic group, the final glycemia reached the value of 309.8 ± 170.83 mg/dl ; thereby obtaining a highly significant difference(p<0.0003). It is concluded that the omega 3 fatty acids significantly reduce hyperglycemia in diabetes induced in Rattus rattus variety albinus to normal.